VCA nanobodies target N-WASp to reduce invadopodium formation and functioning

Invasive cancer cells develop small actin-based protrusions called invadopodia, which perform a primordial role in metastasis and extracellular matrix remodelling. Neural Wiskott-Aldrich syndrome protein (N-WASp) is a scaffold protein which can directly bind to actin monomers and Arp2/3 and is a cru...

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Bibliographic Details
Published in:PLoS One
Main Authors: Hebbrecht, Tim, Van Audenhove, Isabel, Zwaenepoel, Olivier, Verhelle, Adriaan, Gettemans, Jan
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5609757/
https://ncbi.nlm.nih.gov/pubmed/28938008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0185076
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