Replication Stress Induces Global Chromosome Breakage in the Fragile X Genome

Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by mutations in the FMR1 gene and deficiency of a functional FMRP protein. FMRP is known as a translation repressor whose nuclear function is not understood. We investigated the global impact on genome stability due to FMRP loss. Using...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Chakraborty, Arijita, Jenjaroenpun, Piroon, Li, Jing, El Hilali, Sami, McCulley, Andrew, Haarer, Brian, Hoffman, Elizabeth A., Belak, Aimee, Thorland, Audrey, Hehnly, Heidi, Schildkraut, Carl, Chen, Chun-long, Kuznetsov, Vladimir A., Feng, Wenyi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7549430/
https://ncbi.nlm.nih.gov/pubmed/32966779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108179
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