Replication Stress Induces Global Chromosome Breakage in the Fragile X Genome

Summary: Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by mutations in the FMR1 gene and deficiency of a functional FMRP protein. FMRP is known as a translation repressor whose nuclear function is not understood. We investigated the global impact on genome stability due to FMRP lo...

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Detalhes bibliográficos
Main Authors: Arijita Chakraborty, Piroon Jenjaroenpun, Jing Li, Sami El Hilali, Andrew McCulley, Brian Haarer, Elizabeth A. Hoffman, Aimee Belak, Audrey Thorland, Heidi Hehnly, Carl Schildkraut, Chun-long Chen, Vladimir A. Kuznetsov, Wenyi Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020-09-01
Colecção:Cell Reports
Assuntos:
fragile X syndrome
FXS
FMRP
I304N
DNA double-strand breaks
DSB
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211124720311682
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