Break-seq reveals hydroxyurea-induced chromosome fragility as a result of unscheduled conflict between DNA replication and transcription

We have previously demonstrated that in Saccharomyces cerevisiae replication, checkpoint inactivation via a mec1 mutation leads to chromosome breakage at replication forks initiated from virtually all origins after transient exposure to hydroxyurea (HU), an inhibitor of ribonucleotide reductase. Her...

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Udgivet i:Genome Res
Main Authors: Hoffman, Elizabeth A., McCulley, Andrew, Haarer, Brian, Arnak, Remigiusz, Feng, Wenyi
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352882/
https://ncbi.nlm.nih.gov/pubmed/25609572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.180497.114
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