Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793

[Image: see text] The orexin system consists of two neuropeptides (orexin-A and orexin-B) that exert their mode of action on two receptors (orexin-1 and orexin-2). While the role of the orexin-2 receptor is established as an important modulator of sleep wake states, the role of the orexin-1 receptor...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Préville, Cathy, Bonaventure, Pascal, Koudriakova, Tatiana, Lord, Brian, Nepomuceno, Diane, Rizzolio, Michele, Mani, Neelakandha, Coe, Kevin J., Ndifor, Anthony, Dugovic, Christine, Dvorak, Curt A., Coate, Heather, Pippel, Daniel J., Fitzgerald, Anne, Allison, Brett, Lovenberg, Timothy W., Carruthers, Nicholas I., Shireman, Brock T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2020
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7549262/
https://ncbi.nlm.nih.gov/pubmed/33062185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00085
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