Modulation of glycosyltransferase ST6Gal-I in gastric cancer-derived organoids disrupts homeostatic epithelial cell turnover

Programmed cell death promotes homeostatic cell turnover in the epithelium but is dysregulated in cancer. The glycosyltransferase ST6Gal-I is known to block homeostatic apoptosis through α2,6-linked sialylation of the death receptor TNFR1 in many cell types. However, its role has not been investigat...

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Udgivet i:J Biol Chem
Main Authors: Alexander, Katie L., Serrano, Carolina A., Chakraborty, Asmi, Nearing, Marie, Council, Leona N., Riquelme, Arnoldo, Garrido, Marcelo, Bellis, Susan L., Smythies, Lesley E., Smith, Phillip D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2020
Fag:
Glycobiology and Extracellular Matrices
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7549044/
https://ncbi.nlm.nih.gov/pubmed/32763973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014887
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