Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection

Coronaviruses have caused several zoonotic infections in the past two decades, leading to significant morbidity and mortality globally. Balanced regulation of cell death and inflammatory immune responses is essential to promote protection against coronavirus infection; however, the underlying mechan...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Zheng, Min, Williams, Evan Peter, Malireddi, R. K. Subbarao, Karki, Rajendra, Banoth, Balaji, Burton, Amanda, Webby, Richard, Channappanavar, Rudragouda, Jonsson, Colleen Beth, Kanneganti, Thirumala-Devi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7549031/
https://ncbi.nlm.nih.gov/pubmed/32763970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015036
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