The nonreceptor tyrosine kinase SYK drives caspase-8/NLRP3 inflammasome-mediated autoinflammatory osteomyelitis

Chronic recurrent multifocal osteomyelitis (CRMO) in humans can be modeled in Pstpip2(cmo) mice, which carry a missense mutation in the proline–serine–threonine phosphatase–interacting protein 2 (Pstpip2) gene. As cmo disease in mice, the experimental model analogous to human CRMO, is mediated speci...

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Опубликовано в: :J Biol Chem
Главные авторы: Dasari, Tejasvi K., Geiger, Rechel, Karki, Rajendra, Banoth, Balaji, Sharma, Bhesh Raj, Gurung, Prajwal, Burton, Amanda, Kanneganti, Thirumala-Devi
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2020
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7076204/
https://ncbi.nlm.nih.gov/pubmed/31719149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010623
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