USP7 mediates pathological hepatic de novo lipogenesis through promoting stabilization and transcription of ZNF638

Aberrant de novo lipogenesis (DNL) results in excessive hepatic lipid accumulation and liver steatosis, the causative factors of many liver diseases, such as non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and hepatocellular carcinoma (HCC). However, the underlying m...

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Bibliografische gegevens
Gepubliceerd in:Cell Death Dis
Hoofdauteurs: Ni, Wenkai, Lin, Shengli, Bian, Saiyan, Zheng, Wenjie, Qu, Lishuai, Fan, Yihui, Lu, Cuihua, Xiao, Mingbing, Zhou, Pinghong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7548010/
https://ncbi.nlm.nih.gov/pubmed/33040080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03075-8
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