USP7 mediates pathological hepatic de novo lipogenesis through promoting stabilization and transcription of ZNF638

Aberrant de novo lipogenesis (DNL) results in excessive hepatic lipid accumulation and liver steatosis, the causative factors of many liver diseases, such as non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and hepatocellular carcinoma (HCC). However, the underlying m...

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Опубликовано в: :Cell Death Dis
Главные авторы: Ni, Wenkai, Lin, Shengli, Bian, Saiyan, Zheng, Wenjie, Qu, Lishuai, Fan, Yihui, Lu, Cuihua, Xiao, Mingbing, Zhou, Pinghong
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7548010/
https://ncbi.nlm.nih.gov/pubmed/33040080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03075-8
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