USP7 mediates pathological hepatic de novo lipogenesis through promoting stabilization and transcription of ZNF638

Aberrant de novo lipogenesis (DNL) results in excessive hepatic lipid accumulation and liver steatosis, the causative factors of many liver diseases, such as non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and hepatocellular carcinoma (HCC). However, the underlying m...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Ni, Wenkai, Lin, Shengli, Bian, Saiyan, Zheng, Wenjie, Qu, Lishuai, Fan, Yihui, Lu, Cuihua, Xiao, Mingbing, Zhou, Pinghong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7548010/
https://ncbi.nlm.nih.gov/pubmed/33040080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03075-8
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