Quality-control mechanisms targeting translationally stalled and C-terminally extended poly(GR) associated with ALS/FTD

Maintaining the fidelity of nascent peptide chain (NP) synthesis is essential for proteome integrity and cellular health. Ribosome-associated quality control (RQC) serves to resolve stalled translation, during which untemplated Ala/Thr residues are added C terminally to stalled peptide, as shown dur...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Li, Shuangxi, Wu, Zhihao, Tantray, Ishaq, Li, Yu, Chen, Songjie, Dong, Jason, Glynn, Steven, Vogel, Hannes, Snyder, Michael, Lu, Bingwei
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7547246/
https://ncbi.nlm.nih.gov/pubmed/32958650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2005506117
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