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Quality-control mechanisms targeting translationally stalled and C-terminally extended poly(GR) associated with ALS/FTD
Maintaining the fidelity of nascent peptide chain (NP) synthesis is essential for proteome integrity and cellular health. Ribosome-associated quality control (RQC) serves to resolve stalled translation, during which untemplated Ala/Thr residues are added C terminally to stalled peptide, as shown dur...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7547246/ https://ncbi.nlm.nih.gov/pubmed/32958650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2005506117 |
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