FTD/ALS-associated poly(GR) protein impairs the Notch pathway and is recruited by poly(GA) into cytoplasmic inclusions

C9ORF72 repeat expansion is the most common genetic mutation in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Abnormal dipeptide repeat proteins (DPRs) generated from repeat-associated non-AUG (RAN) translation of repeat-containing RNAs are thought to be pathogenic; however,...

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Bibliographic Details
Published in:Acta Neuropathol
Main Authors: Yang, Dejun, Abdallah, Abbas, Li, Zhaodong, Lu, Yubing, Almeida, Sandra, Gao, Fen-Biao
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2015
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575383/
https://ncbi.nlm.nih.gov/pubmed/26031661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-015-1448-6
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