C9ORF72-ALS/FTD-associated poly(GR) binds Atp5a1 and compromises mitochondrial function in vivo

The GGGGCC repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, it is not known which dysregulated molecular pathways are primarily responsible for disease initiation or progression. We established an inducibl...

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Udgivet i:Nat Neurosci
Main Authors: Choi, So Yoen, Lopez-Gonzalez, Rodrigo, Krishnan, Gopinath, Phillips, Hannah L., Li, Alissa Nana, Seeley, William W., Yao, Wei-Dong, Almeida, Sandra, Gao, Fen-Biao
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800116/
https://ncbi.nlm.nih.gov/pubmed/31086314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-019-0397-0
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