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C9ORF72-ALS/FTD-associated poly(GR) binds Atp5a1 and compromises mitochondrial function in vivo

The GGGGCC repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, it is not known which dysregulated molecular pathways are primarily responsible for disease initiation or progression. We established an inducibl...

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Vydáno v:Nat Neurosci
Hlavní autoři: Choi, So Yoen, Lopez-Gonzalez, Rodrigo, Krishnan, Gopinath, Phillips, Hannah L., Li, Alissa Nana, Seeley, William W., Yao, Wei-Dong, Almeida, Sandra, Gao, Fen-Biao
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800116/
https://ncbi.nlm.nih.gov/pubmed/31086314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-019-0397-0
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