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Partial inhibition of the overactivated Ku80-dependent DNA repair pathway rescues neurodegeneration in C9ORF72-ALS/FTD

GGGGCC (G(4)C(2)) repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). One class of major pathogenic molecules in C9ORF72-ALS/FTD is dipeptide repeat proteins such as poly(GR), whose toxicity has been well documented i...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Lopez-Gonzalez, Rodrigo, Yang, Dejun, Pribadi, Mochtar, Kim, Tanya S., Krishnan, Gopinath, Choi, So Yoen, Lee, Soojin, Coppola, Giovanni, Gao, Fen-Biao
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511021/
https://ncbi.nlm.nih.gov/pubmed/31019093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1901313116
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