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Base Editing Mediated Generation of Point Mutations Into Human Pluripotent Stem Cells for Modeling Disease
Human pluripotent stem cells (hPSCs) are a powerful platform for disease modeling and drug discovery. However, the introduction of known pathogenic mutations into hPSCs is a time-consuming and labor-intensive process. Base editing is a newly developed technology that enables facile introduction of p...
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| Publié dans: | Front Cell Dev Biol |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Frontiers Media S.A.
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7546412/ https://ncbi.nlm.nih.gov/pubmed/33102492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.590581 |
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