Base Editing Mediated Generation of Point Mutations Into Human Pluripotent Stem Cells for Modeling Disease

Human pluripotent stem cells (hPSCs) are a powerful platform for disease modeling and drug discovery. However, the introduction of known pathogenic mutations into hPSCs is a time-consuming and labor-intensive process. Base editing is a newly developed technology that enables facile introduction of p...

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Vydáno v:Front Cell Dev Biol
Hlavní autoři: Qi, Tao, Wu, Fujian, Xie, Yuquan, Gao, Siqi, Li, Miaomiao, Pu, Jun, Li, Dali, Lan, Feng, Wang, Yongming
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Cell and Developmental Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7546412/
https://ncbi.nlm.nih.gov/pubmed/33102492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.590581
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