Statin suppresses sirtuin 6 through miR-495, increasing FoxO1-dependent hepatic gluconeogenesis

Rationale: Statin, the most widely used medication in lowering cholesterol, is also associated with increased risk of type 2 diabetes, but its molecular basis remains unclear. Methods: Mice were injected intraperitoneally with statins alone or in combination with sirtuin (Sirt) 6 activator, and bloo...

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Bibliografiske detaljer
Udgivet i:Theranostics
Main Authors: Shi, Min Yan, Bang, In Hyuk, Han, Chang Yeob, Lee, Dae Ho, Park, Byung-Hyun, Bae, Eun Ju
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2020
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7545997/
https://ncbi.nlm.nih.gov/pubmed/33052223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.49770
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