Systemic Anti–PD-1 Immunotherapy Results in PD-1 Blockade on T Cells in the Cerebrospinal Fluid

IMPORTANCE: Little is known about the penetration and bioactivity of systemically administered programmed cell death 1 (PD-1) antibodies in the central nervous system. Such information is critical for advancing checkpoint antibody therapies for treatment of brain tumors. OBJECTIVE: To evaluate pembr...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:JAMA Oncol
Main Authors: Portnow, Jana, Wang, Dongrui, Blanchard, M. Suzette, Tran, Vivi, Alizadeh, Darya, Starr, Renate, Dodia, Ramsinh, Chiu, Vivian, Brito, Alfonso, Kilpatrick, Julie, McNamara, Paige, Forman, Stephen J., Badie, Behnam, Synold, Timothy W., Brown, Christine E.
Format: Artigo
Jezik:Inglês
Izdano: American Medical Association 2020
Teme:
Brief Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7545351/
https://ncbi.nlm.nih.gov/pubmed/33030521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2020.4508
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