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Reconstruction of clone- and haplotype-specific cancer genome karyotypes from bulk tumor samples

Many cancer genomes are extensively rearranged with aberrant chromosomal karyotypes. Deriving these karyotypes from high-throughput DNA sequencing of bulk tumor samples is complicated because most tumors are a heterogeneous mixture of normal cells and subpopulations of cancer cells, or clones, that...

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Bibliographic Details
Published in:Genome Res
Main Authors: Aganezov, Sergey, Raphael, Benjamin J.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7545144/
https://ncbi.nlm.nih.gov/pubmed/32887685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.256701.119
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