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Reconstruction of clone- and haplotype-specific cancer genome karyotypes from bulk tumor samples
Many cancer genomes are extensively rearranged with aberrant chromosomal karyotypes. Deriving these karyotypes from high-throughput DNA sequencing of bulk tumor samples is complicated because most tumors are a heterogeneous mixture of normal cells and subpopulations of cancer cells, or clones, that...
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| Published in: | Genome Res |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Cold Spring Harbor Laboratory Press
2020
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7545144/ https://ncbi.nlm.nih.gov/pubmed/32887685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.256701.119 |
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