Somatic structural variation targets neurodevelopmental genes and identifies SHANK2 as a tumor suppressor in neuroblastoma

Neuroblastoma is a malignancy of the developing sympathetic nervous system that accounts for 12% of childhood cancer deaths. Like many childhood cancers, neuroblastoma shows a relative paucity of somatic single-nucleotide variants (SNVs) and small insertions and deletions (indels) compared to adult...

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Dettagli Bibliografici
Pubblicato in:Genome Res
Autori principali: Lopez, Gonzalo, Conkrite, Karina L., Doepner, Miriam, Rathi, Komal S., Modi, Apexa, Vaksman, Zalman, Farra, Lance M., Hyson, Eric, Noureddine, Moataz, Wei, Jun S., Smith, Malcolm A., Asgharzadeh, Shahab, Seeger, Robert C., Khan, Javed, Auvil, Jaime Guidry, Gerhard, Daniela S., Maris, John M., Diskin, Sharon J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2020
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7545140/
https://ncbi.nlm.nih.gov/pubmed/32796005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.252106.119
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