Clinically Relevant Cytotoxic Immune Cell Signatures and Clonal Expansion of T Cell Receptors in High-risk MYCN-not-amplified Human Neuroblastoma

PURPOSE: High-risk neuroblastoma is an aggressive disease. DNA sequencing studies have revealed a paucity of actionable genomic alterations and a low mutation burden, posing challenges to develop effective novel therapies. We used RNA sequencing (RNA-seq) to investigate the biology of this disease i...

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Publicado no:Clin Cancer Res
Main Authors: Wei, Jun S., Kuznetsov, Igor B., Zhang, Shile, Song, Young K., Asgharzadeh, Shahab, Sindiri, Sivasish, Wen, Xinyu, Patidar, Rajesh, Najaraj, Sushma, Walton, Ashley, Auvil, Jaime M. Guidry, Gerhard, Daniela S., Yuksel, Aysen, Catchpoole, Daniel, Hewitt, Stephen M., Sondel, Paul M., Seeger, Robert, Maris, John M., Khan, Javed
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6504934/
https://ncbi.nlm.nih.gov/pubmed/29784674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0599
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