Clinically Relevant Cytotoxic Immune Cell Signatures and Clonal Expansion of T Cell Receptors in High-risk MYCN-not-amplified Human Neuroblastoma

PURPOSE: High-risk neuroblastoma is an aggressive disease. DNA sequencing studies have revealed a paucity of actionable genomic alterations and a low mutation burden, posing challenges to develop effective novel therapies. We used RNA sequencing (RNA-seq) to investigate the biology of this disease i...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Wei, Jun S., Kuznetsov, Igor B., Zhang, Shile, Song, Young K., Asgharzadeh, Shahab, Sindiri, Sivasish, Wen, Xinyu, Patidar, Rajesh, Najaraj, Sushma, Walton, Ashley, Auvil, Jaime M. Guidry, Gerhard, Daniela S., Yuksel, Aysen, Catchpoole, Daniel, Hewitt, Stephen M., Sondel, Paul M., Seeger, Robert, Maris, John M., Khan, Javed
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6504934/
https://ncbi.nlm.nih.gov/pubmed/29784674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0599
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