HLA-B*14:01 and HLA-B*35:01 are associated with trimethoprim-sulfamethoxazole induced liver injury

BACKGROUND AND AIM: Trimethoprim-sulfamethoxazole (TMP-SMX) is an important cause of idiosyncratic drug induced liver injury (DILI), but its genetic risk factors are not well understood. We investigated the relationship between variants in the HLA Class I and II genes and well characterized cases of...

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Publicat a:Hepatology
Autors principals: Li, Yi-Ju, Phillips, Elizabeth, Dellinger, Andrew, Nicoletti, Paola, Schutte, Ryan, Li, Danmeng, Ostrov, David A., Fontana, Robert J., Watkins, Paul B., Stolz, Andrew, Daly, Ann K, Aithal, Guruprasad P, Barnhart, Huiman, Chalasani, Naga
Format: Artigo
Idioma:Inglês
Publicat: 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544638/
https://ncbi.nlm.nih.gov/pubmed/32270503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.31258
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