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Computationally designed cyclic peptides derived from an antibody loop increase breadth of binding for influenza variants
The influenza hemagglutinin (HA) glycoprotein is the target of many broadly neutralizing antibodies. However, influenza viruses can rapidly escape antibody recognition by mutation of hypervariable regions of HA that overlap with the binding epitope. We hypothesized that by designing peptides to mimi...
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| Publicado no: | Structure |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7544621/ https://ncbi.nlm.nih.gov/pubmed/32610044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2020.04.005 |
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