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Genome-wide effects of the antimicrobial peptide apidaecin on translation termination in bacteria

Biochemical studies suggested that the antimicrobial peptide apidaecin (Api) inhibits protein synthesis by binding in the nascent peptide exit tunnel and trapping the release factor associated with a terminating ribosome. The mode of Api action in bacterial cells had remained unknown. Here genome-wi...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Mangano, Kyle, Florin, Tanja, Shao, Xinhao, Klepacki, Dorota, Chelysheva, Irina, Ignatova, Zoya, Gao, Yu, Mankin, Alexander S, Vázquez-Laslop, Nora
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544508/
https://ncbi.nlm.nih.gov/pubmed/33031031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.62655
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