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Pre-treatment twice with liposomal clodronate protects against acetaminophen hepatotoxicity through a pre-conditioning effect

BACKGROUND AND AIM: Acetaminophen (APAP) overdose is a major cause of acute liver injury, but the role of macrophages in propagation of the hepatotoxicity is controversial. Early research revealed that macrophage inhibitors protect against APAP injury. However, later work demonstrated that macrophag...

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Detalhes bibliográficos
Publicado no:Liver Res
Main Authors: Clemens, Melissa M., Vazquez, Joel H., Kennon-McGill, Stefanie, McCullough, Sandra S., James, Laura P., McGill, Mitchell R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544241/
https://ncbi.nlm.nih.gov/pubmed/33042596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.livres.2020.07.002
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