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Pre-treatment twice with liposomal clodronate protects against acetaminophen hepatotoxicity through a pre-conditioning effect

BACKGROUND AND AIM: Acetaminophen (APAP) overdose is a major cause of acute liver injury, but the role of macrophages in propagation of the hepatotoxicity is controversial. Early research revealed that macrophage inhibitors protect against APAP injury. However, later work demonstrated that macrophag...

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Bibliografske podrobnosti
izdano v:Liver Res
Main Authors: Clemens, Melissa M., Vazquez, Joel H., Kennon-McGill, Stefanie, McCullough, Sandra S., James, Laura P., McGill, Mitchell R.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544241/
https://ncbi.nlm.nih.gov/pubmed/33042596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.livres.2020.07.002
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