A ribosomal RNA fragment with 2′,3′-cyclic phosphate and GTP-binding activity acts as RIG-I ligand

The RNA helicase RIG-I plays a key role in sensing pathogen-derived RNA. Double-stranded RNA structures bearing 5′-tri- or diphosphates are commonly referred to as activating RIG-I ligands. However, endogenous RNA fragments generated during viral infection via RNase L also activate RIG-I. Of note, R...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Jung, Stephanie, von Thülen, Tina, Yang, Ines, Laukemper, Viktoria, Rupf, Benjamin, Janga, Harshavardhan, Panagiotidis, Georgios-Dimitrios, Schoen, Andreas, Nicolai, Marina, Schulte, Leon N, Obermann, Hannah-Lena, Weber, Friedemann, Kaufmann, Andreas, Bauer, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544222/
https://ncbi.nlm.nih.gov/pubmed/32946572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa739
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