A Single Naturally Occurring 2’-O-Methylation Converts a TLR7- and TLR8-Activating RNA into a TLR8-Specific Ligand

TLR7 and TLR8 recognize RNA from pathogens and lead to subsequent immune stimulation. Here we demonstrate that a single naturally occurring 2’-O-methylation within a synthetic 18s rRNA derived RNA sequence prevents IFN-α production, however secretion of proinflammatory cytokines such as IL-6 is not...

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Publicat a:PLoS One
Autors principals: Jung, Stephanie, von Thülen, Tina, Laukemper, Viktoria, Pigisch, Stephanie, Hangel, Doris, Wagner, Hermann, Kaufmann, Andreas, Bauer, Stefan
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364935/
https://ncbi.nlm.nih.gov/pubmed/25785446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120498
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