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Modeling the efficiency of filovirus entry into cells in vitro: Effects of SNP mutations in the receptor molecule

Interaction between filovirus glycoprotein (GP) and the Niemann-Pick C1 (NPC1) protein is essential for membrane fusion during virus entry. Some single-nucleotide polymorphism (SNPs) in two surface-exposed loops of NPC1 are known to reduce viral infectivity. However, the dependence of differences in...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:PLoS Comput Biol
Main Authors: Kim, Kwang Su, Kondoh, Tatsunari, Asai, Yusuke, Takada, Ayato, Iwami, Shingo
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2020
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544041/
https://ncbi.nlm.nih.gov/pubmed/32986692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007612
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