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Modeling the efficiency of filovirus entry into cells in vitro: Effects of SNP mutations in the receptor molecule
Interaction between filovirus glycoprotein (GP) and the Niemann-Pick C1 (NPC1) protein is essential for membrane fusion during virus entry. Some single-nucleotide polymorphism (SNPs) in two surface-exposed loops of NPC1 are known to reduce viral infectivity. However, the dependence of differences in...
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| Udgivet i: | PLoS Comput Biol |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7544041/ https://ncbi.nlm.nih.gov/pubmed/32986692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007612 |
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