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Nuclear body phase separation drives telomere clustering in ALT cancer cells
Telomerase-free cancer cells employ a recombination-based alternative lengthening of telomeres (ALT) pathway that depends on ALT-associated promyelocytic leukemia nuclear bodies (APBs), whose function is unclear. We find that APBs behave as liquid condensates in response to telomere DNA damage, sugg...
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| Publicado en: | Mol Biol Cell |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The American Society for Cell Biology
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7543070/ https://ncbi.nlm.nih.gov/pubmed/32579423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E19-10-0589 |
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