Low dose Hsp90 inhibitor selectively radiosensitizes HNSCC and Pancreatic xenografts

PURPOSE: Treatment approaches using Hsp90 inhibitors at their maximum tolerated doses have not produced selective tumor toxicity. Inhibition of Hsp90 activity causes degradation of client proteins including those involved in recognizing and repairing DNA lesions. We hypothesized that if DNA repair p...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Mehta, Ranjit K, Pal, Sanjima, Kondapi, Koushik, Sitto, Merna, Dewar, Cuyler, Devasia, Theresa, Schipper, Matthew J, Thomas, Dafydd G, Basrur, Venkatesha, Pai, Manjunath P., Morishima, Yoshihiro, Osawa, Yoichi, Pratt, William B, Lawrence, Theodore S, Nyati, Mukesh K
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7541797/
https://ncbi.nlm.nih.gov/pubmed/32718999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-3102
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados