Structural Basis of the Activation of Heterotrimeric Gs-protein by Isoproterenol-bound β(1)-Adrenergic Receptor

Cardiac disease remains the leading causes of morbidity and mortality worldwide. The β(1)-adrenergic receptor (β(1)-AR) is a major regulator of cardiac functions and is down-regulated in the majority of heart failure cases. A key physiological process is the activation of heterotrimeric G-protein Gs...

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Pubblicato in:Mol Cell
Autori principali: Su, Minfei, Zhu, Lan, Zhang, Yixiao, Paknejad, Navid, Dey, Raja, Huang, Jianyun, Lee, Ming-Yue, Williams, Dewight, Jordan, Kelsey D., Eng, Edward T., Ernst, Oliver P., Meyerson, Joel R., Hite, Richard K., Walz, Thomas, Liu, Wei, Huang, Xin-Yun
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7541785/
https://ncbi.nlm.nih.gov/pubmed/32818430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.08.001
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