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Using Sulfuramidimidoyl Fluorides that Undergo Sulfur(VI) Fluoride Exchange for Inverse Drug Discovery
Drug candidates that form covalent linkages with their target proteins have been under-explored compared to conventional counterparts that modulate biological function by reversible binding to proteins, in part due to concerns about off-target reactivity. But toxicity linked to off-target reactivity...
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| הוצא לאור ב: | Nat Chem |
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| Main Authors: | , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2020
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7541551/ https://ncbi.nlm.nih.gov/pubmed/32868886 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-020-0530-4 |
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