Using Sulfuramidimidoyl Fluorides that Undergo Sulfur(VI) Fluoride Exchange for Inverse Drug Discovery

Drug candidates that form covalent linkages with their target proteins have been under-explored compared to conventional counterparts that modulate biological function by reversible binding to proteins, in part due to concerns about off-target reactivity. But toxicity linked to off-target reactivity...

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Publicado no:Nat Chem
Main Authors: Brighty, Gabriel J., Botham, Rachel C., Li, Suhua, Nelson, Luke, Mortenson, David E., Li, Gencheng, Morisseau, Christophe, Wang, Hua, Hammock, Bruce D., Sharpless, K. Barry, Kelly, Jeffery W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7541551/
https://ncbi.nlm.nih.gov/pubmed/32868886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-020-0530-4
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