“Inverse Drug Discovery” strategy to identify proteins that are targeted by latent electrophiles – exemplified by arylfluorosulfates

Drug candidates are generally discovered using biochemical screens employing an isolated target protein or by utilizing cell-based phenotypic assays. Both non-covalent and covalent hits emerge from such endeavors. Herein, we exemplify an “Inverse Drug Discovery” strategy in which organic compounds o...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Am Chem Soc
Egile Nagusiak: Mortenson, David E., Brighty, Gabriel J., Plate, Lars, Bare, Grant, Chen, Wentao, Li, Suhua, Wang, Hua, Cravatt, Benjamin F., Forli, Stefano, Powers, Evan T., Sharpless, K. Barry, Wilson, Ian A., Kelly, Jeffery W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762408/
https://ncbi.nlm.nih.gov/pubmed/29265822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b08366
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak