Inhibition of O-GlcNAc transferase renders prostate cancer cells dependent on CDK9

O-GlcNAc transferase (OGT) is a nutrient-sensitive glycosyltransferase that is overexpressed in prostate cancer, the most common cancer in males. We recently developed specific and potent inhibitor targeting this enzyme, and here we report a synthetic lethality screen using this compound. Our screen...

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Détails bibliographiques
Publié dans:Mol Cancer Res
Auteurs principaux: Itkonen, Harri M., Poulose, Ninu, Steele, Rebecca E., Martin, Sara E. S., Levine, Zebulon G., Duveau, Damien Y., Carelli, Ryan, Singh, Reema, Urbanucci, Alfonso, Loda, Massimo, Thomas, Craig J, Mills, Ian G., Walker, Suzanne
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7541471/
https://ncbi.nlm.nih.gov/pubmed/32611550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-20-0339
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