Lack of airway submucosal glands impairs respiratory host defenses

Submucosal glands (SMGs) are a prominent structure that lines human cartilaginous airways. Although it has been assumed that SMGs contribute to respiratory defense, that hypothesis has gone without a direct test. Therefore, we studied pigs, which have lungs like humans, and disrupted the gene for ec...

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Pubblicato in:eLife
Autori principali: Ostedgaard, Lynda S, Price, Margaret P, Whitworth, Kristin M, Abou Alaiwa, Mahmoud H, Fischer, Anthony J, Warrier, Akshaya, Samuel, Melissa, Spate, Lee D, Allen, Patrick D, Hilkin, Brieanna M, Romano Ibarra, Guillermo S, Ortiz Bezara, Miguel E, Goodell, Brian J, Mather, Steven E, Powers, Linda S, Stroik, Mallory R, Gansemer, Nicholas D, Hippee, Camilla E, Zarei, Keyan, Goeken, J Adam, Businga, Thomas R, Hoffman, Eric A, Meyerholz, David K, Prather, Randall S, Stoltz, David A, Welsh, Michael J
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2020
Soggetti:
Medicine
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7541087/
https://ncbi.nlm.nih.gov/pubmed/33026343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.59653
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