Lack of airway submucosal glands impairs respiratory host defenses

Submucosal glands (SMGs) are a prominent structure that lines human cartilaginous airways. Although it has been assumed that SMGs contribute to respiratory defense, that hypothesis has gone without a direct test. Therefore, we studied pigs, which have lungs like humans, and disrupted the gene for ec...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Ostedgaard, Lynda S, Price, Margaret P, Whitworth, Kristin M, Abou Alaiwa, Mahmoud H, Fischer, Anthony J, Warrier, Akshaya, Samuel, Melissa, Spate, Lee D, Allen, Patrick D, Hilkin, Brieanna M, Romano Ibarra, Guillermo S, Ortiz Bezara, Miguel E, Goodell, Brian J, Mather, Steven E, Powers, Linda S, Stroik, Mallory R, Gansemer, Nicholas D, Hippee, Camilla E, Zarei, Keyan, Goeken, J Adam, Businga, Thomas R, Hoffman, Eric A, Meyerholz, David K, Prather, Randall S, Stoltz, David A, Welsh, Michael J
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7541087/
https://ncbi.nlm.nih.gov/pubmed/33026343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.59653
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