TGFβ1 Induces Axonal Outgrowth via ALK5/PKA/SMURF1-Mediated Degradation of RhoA and Stabilization of PAR6

Transforming growth factor (TGF)β1 has repeatedly been associated with axonal regeneration and recovery after injury to the CNS. We found TGFβ1 upregulated in the stroke-denervated mouse spinal cord after ischemic injury to the motor cortex as early as 4 d postinjury (dpi) and persisting up to 28 dp...

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Publicat a:eNeuro
Autors principals: Kaiser, Julia, Maibach, Martina, Piovesana, Ester, Salpeter, Iris, Escher, Nora, Ormen, Yannick, Schwab, Martin E.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2020
Matèries:
Research Article: New Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7540929/
https://ncbi.nlm.nih.gov/pubmed/32887692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0104-20.2020
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