Biophysical basis for Kv1.3 regulation of membrane potential changes induced by P2X4‐mediated calcium entry in microglia

Microglia‐mediated inflammation exerts adverse effects in ischemic stroke and in neurodegenerative disorders such as Alzheimer's disease (AD). Expression of the voltage‐gated potassium channel Kv1.3 is required for microglia activation. Both genetic deletion and pharmacological inhibition of Kv...

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Detalhes bibliográficos
Publicado no:Glia
Main Authors: Nguyen, Hai M., di Lucente, Jacopo, Chen, Yi‐Je, Cui, Yanjun, Ibrahim, Rania H., Pennington, Michael W., Jin, Lee‐Way, Maezawa, Izumi, Wulff, Heike
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7540709/
https://ncbi.nlm.nih.gov/pubmed/32525239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.23847
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