K(v)1.3 inhibition as a potential microglia-targeted therapy for Alzheimer’s disease: preclinical proof of concept

Microglia significantly contribute to the pathophysiology of Alzheimer’s disease but an effective microglia-targeted therapeutic approach is not yet available clinically. The potassium channels K(v)1.3 and K(ir)2.1 play important roles in regulating immune cell functions and have been implicated by...

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Publicado en:Brain
Autores principales: Maezawa, Izumi, Nguyen, Hai M, Di Lucente, Jacopo, Jenkins, David Paul, Singh, Vikrant, Hilt, Silvia, Kim, Kyoungmi, Rangaraju, Srikant, Levey, Allan I, Wulff, Heike, Jin, Lee-Way
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837198/
https://ncbi.nlm.nih.gov/pubmed/29272333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awx346
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