Assessment of romiplostim immunogenicity in adult patients in clinical trials and in a global postmarketing registry

Antibodies to first‐generation recombinant thrombopoietin (TPO) neutralized endogenous TPO and caused thrombocytopenia in some healthy subjects and chemotherapy patients. The second‐generation TPO receptor agonist romiplostim, having no sequence homology to TPO, was developed to avoid immunogenicity...

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Detaylı Bibliyografya
Yayımlandı:Br J Haematol
Asıl Yazarlar: Mytych, Daniel T., Park, Joseph K., Kim, June, Barger, Troy E., Boshier, Andy, Jawa, Vibha, Kuter, David J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2020
Konular:
Platelets Haemostasis and Thrombosis
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7540503/
https://ncbi.nlm.nih.gov/pubmed/32311075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.16658
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