Antinociceptive Effects of Lipid Raft Disruptors, a Novel Carboxamido-Steroid and Methyl β-Cyclodextrin, in Mice by Inhibiting Transient Receptor Potential Vanilloid 1 and Ankyrin 1 Channel Activation

Transient Receptor Potential Vanilloid 1 and Ankyrin 1 (TRPV1, TRPA1) cation channels are expressed in nociceptive primary sensory neurons, and play an integrative role in pain processing and inflammatory functions. Lipid rafts are liquid-ordered plasma membrane microdomains rich in cholesterol, sph...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Horváth, Ádám, Biró-Sütő, Tünde, Kántás, Boglárka, Payrits, Maja, Skoda-Földes, Rita, Szánti-Pintér, Eszter, Helyes, Zsuzsanna, Szőke, Éva
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7539994/
https://ncbi.nlm.nih.gov/pubmed/33071817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.559109
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