Analgesic Effects of Lipid Raft Disruption by Sphingomyelinase and Myriocin via Transient Receptor Potential Vanilloid 1 and Transient Receptor Potential Ankyrin 1 Ion Channel Modulation

Transient Receptor Potential (TRP) Vanilloid 1 and Ankyrin 1 (TRPV1, TRPA1) cation channels are expressed in nociceptive primary sensory neurons, and integratively regulate nociceptor and inflammatory functions. Lipid rafts are liquid-ordered plasma membrane microdomains rich in cholesterol, sphingo...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Horváth, Ádám, Payrits, Maja, Steib, Anita, Kántás, Boglárka, Biró-Süt, Tünde, Erostyák, János, Makkai, Géza, Sághy, Éva, Helyes, Zsuzsanna, Szőke, Éva
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7873636/
https://ncbi.nlm.nih.gov/pubmed/33584270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.593319
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