Genome-wide synthetic lethal CRISPR screen identifies FIS1 as a genetic interactor of ALS-linked C9ORF72

Mutations in the C9ORF72 gene are the most common cause of amyotrophic lateral sclerosis (ALS). Both toxic gain of function and loss of function pathogenic mechanisms have been proposed. Accruing evidence from mouse knockout studies point to a role for C9ORF72 as a regulator of immune function. To p...

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Veröffentlicht in:Brain Res
Hauptverfasser: Chai, Noori, Haney, Michael S., Couthouis, Julien, Morgens, David W., Benjamin, Alyssa, Wu, Kathryn, Ousey, James, Fang, Shirleen, Finer, Sarah, Bassik, Michael C., Gitler, Aaron D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7539795/
https://ncbi.nlm.nih.gov/pubmed/31843624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2019.146601
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