Identification of antibodies with non-overlapping neutralization sites that target coxsackievirus A16

Hand-foot-and-mouth disease is a common childhood illness primarily caused by coxsackievirus A16 (CVA16), for which there are no current vaccines or treatments. We identify three CVA16-specific neutralizing monoclonal antibodies (nAbs) with therapeutic potential, 18A7, 14B10, and NA9D7. We present a...

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Publicat a:Cell Host Microbe
Autors principals: He, Maozhou, Xu, Longfa, Zheng, Qingbing, Zhu, Rui, Yin, Zhichao, Zha, Zhenghui, Lin, Yu, Yang, Lisheng, Huang, Yang, Ye, Xiangzhong, Li, Shuxuan, Hou, Wangheng, Wu, Yangtao, Han, Jinle, Liu, Dongxiao, Li, Zekai, Chen, Zhenqin, Yu, Hai, Que, Yuqiong, Wang, Yingbin, Yan, Xiaodong, Zhang, Jun, Gu, Ying, Zhou, Z. Hong, Cheng, Tong, Li, Shaowei, Xia, Ningshao
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7539366/
https://ncbi.nlm.nih.gov/pubmed/32027857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2020.01.003
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