Anethole Dithiolethione Increases Glutathione in Kidney by Inhibiting γ-Glutamyltranspeptidase: Biochemical Interpretation and Pharmacological Consequences

AIMS: Anethole dithiolethione (ADT) is a marketed drug to treat xerostomia. Its mechanism of action is still unknown, but several preclinical studies indicate that it is able to increase intracellular glutathione (GSH) and protect against oxidative stress. Here, we investigated the molecular mechani...

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Bibliografiske detaljer
Udgivet i:Oxid Med Cell Longev
Main Authors: Giustarini, Daniela, Galvagni, Federico, Dalle-Donne, Isabella, Milzani, Aldo, Lucattelli, Monica, De Cunto, Giovanna, Bartolini, Desirée, Galli, Francesco, Santucci, Annalisa, Rossi, Ranieri
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7539083/
https://ncbi.nlm.nih.gov/pubmed/33062138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/3562972
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