Anethole Dithiolethione Increases Glutathione in Kidney by Inhibiting γ-Glutamyltranspeptidase: Biochemical Interpretation and Pharmacological Consequences

AIMS: Anethole dithiolethione (ADT) is a marketed drug to treat xerostomia. Its mechanism of action is still unknown, but several preclinical studies indicate that it is able to increase intracellular glutathione (GSH) and protect against oxidative stress. Here, we investigated the molecular mechani...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Giustarini, Daniela, Galvagni, Federico, Dalle-Donne, Isabella, Milzani, Aldo, Lucattelli, Monica, De Cunto, Giovanna, Bartolini, Desirée, Galli, Francesco, Santucci, Annalisa, Rossi, Ranieri
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7539083/
https://ncbi.nlm.nih.gov/pubmed/33062138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/3562972
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